Dhea hormone supplement - Benefit and side effects of DHEA supplements - DHEA study review

You MUST read this page - regarding DHEA side effects - before you buy a DHEA supplement

DHEA is short for dehydroepiandrosterone, a hormone made by the adrenal glands located just above the kidneys. Scientists have known about this hormone since 1934. More than 150 hormones are made by the adrenal glands. However, the most abundant hormone made by the adrenal glands is DHEA. After DHEA is made by these glands it goes into the bloodstream, and from then on it travels all over the body and goes into our cells where it is converted into male hormones, known as androgens, and female hormones, known as estrogens. Small amounts of DHEA are also made in the brain by neurons (brain cells).

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DO NOT EXCEED MORE THAN 5 MG A DAY on a long term basis. Blood and saliva testing are not a reliable way to determine DHEA supplement dosage because blood levels do not give a clear view on how DHEA is interacting within each cell in organs and tissues such as brain, skin and hair, liver, breast, prostate, and other parts of the body. It's better to be safe and proceed with caution. You may consider other options to improve your health instead of taking a DHEA supplement. For instance, for sexual health consider an herbal sexual enhancement product such as Passion Rx. For mental health, there are various brain supplements including Mind Power Rx. For appetite control, consider Diet Rx which works great.To improve muscle tissue, consider creatine. For more energy, try MultiVit Rx. If there are not other good options, and if really you do need to take a DHEA supplement, use the smallest amount that works in order to prevent DHEA side effects.

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DHEA safety and danger
We do not feel comfortable with the high dosages of 7-Keto-DHEA supplement, DHEA supplement and pregnenolone sold over the counter. Pregnenolone and DHEA hormones have side effects. A maximum of 5 mg is acceptable when used occasionally. Hormones are powerful substances that have significant short and long term effects. They can be very helpful if used appropriately but can cause serious harm if misused. One of the serious DHEA side effects is heart palpitations or arrhythmias. We have had numerous reports over the years that a DHEA supplement in high doses causes cardiac arrhythmia or skipped heart beats. Use hormones in low doses and for short periods of time.

What are the benefits of DHEA?
DHEA and its sulfate DHEAS are the major circulating adrenal steroids and substrates for peripheral sex hormone biosynthesis. A DHEA supplement may benefit those who have adrenal deficiency and low levels of DHEA. The benefit from a DHEA supplement (in those who are dhea deficient) include improved sense of wellbeing, more alertness and stamina, and enhanced sexual interest and libido. Women who have low DHEA levels usually have low sex drive and some women notice the DHEA benefit of improved libido. Blood levels of all the steroid hormones that derive from DHEA metabolism are often increased when people take a DHEA supplement. This may lead to both beneficial and harmful effects. DHEA has been tested in those with HIV (improved mild depression symptoms) and lupus. The overall DHEA benefit from a supplement must be balanced against DHEA side effects.

What about DHEA side effects?
Dr Ray Sahelian, M.D., author of DHEA: A Practical Guide, has feedback from thousands of people who have taken a DHEA supplement and report DHEA side effects. Individuals with normal levels of DHEA who take high doses are likely get DHEA side effects. Common side effects caused by high doses of a DHEA supplement include:
   Acne - due to androgens. Either DHEA, or the conversion of DHEA into androstenedione or testosterone, cause acne pimples to break out, often within days of starting a DHEA supplement.
   Increased sweat odor and possible scalp itching
   Menstrual irregularities
   Irritability and restlessness - sometimes low doses can actually lead to calmness
   Hair thinning or hair loss
   DHEA has not been tested in combination with other medicines, therefore little is known about drug / hormone interactions. For anecdotes relating to the DHEA side effect of hair loss, read the emails below.
   High doses of DHEA could cause heart palpitations or rhythm disturbances. This is the most serious and potentially life threatening DHEA side effect.
   High DHEA dosing for prolonged periods - many years - could theoretically increase the risk for certain cancers such as breast cancer and prostate cancer.

Q. Re: DHEA side effects. Just a quick note to validate DHEA does cause heart arrhythmia in some people, and I am one of those. I couldn't figure out why I started having palpitations and arrhythmia. I went thru all the tests, and nothing mechanically wrong with my heart. The cardiologist said "I just didn't fit the profile" for anything wrong. So, he wanted to do electrical ablation. I said no, and would wait it out. I stopped taking all my nutritional supplements for 4 months, and the arrhythmia went away. Started taking the DHEA again at 25mg daily, and within 2-3 weeks, the arrhythmia / palpitations had returned. I threw the stuff away! Someone needs to warn people.

DHEA hair loss
Androgenic hormones, such as DHEA, testosterone and androstenedione can cause hair thinning or hair loss in susceptible individuals. DHEA is likely to raise levels of testosterone and dihydrotestosterone (DHT) in the hair follicles. Too much DHT will lead to scalp hair loss in some individuals.
   Taking DHEA when a person’s body does not need it will lead to excess DHT and cause hair loss in many people probably even in one’s 20s. Too many people are taking high dosages of DHEA hormone on a regular basis without really needing it. Anyone who wishes to regain their hair growth should discuss with their physician about stopping the hormone. The temporary (2 to 3 month) use of finasteride (Propecia 1 mg) could stop the hair loss and possibly regrow part or all of the lost hair. It is difficult to predict how long a person would need to take finasteride. Whether hair regrows on its own after stopping DHEA or medicines are necessary to help regrow is not clear at this time.
   Many people have emailed us that DHEA use for several weeks or months led to hair loss. We have had a report from one female DHEA user that her hair loss recovered after she stopped the DHEA.

Q. I started taking DHEA a couple days ago because I have an extremely exhausted adrenal level. I was loosing my life, sleeping 18 hours a day and severe depression. So I heard of DHEA and purchased a bottle of 25 mg, I took one tablet and my LIFE HAS CHANGED, it is awesome, I stay awake, I am not depressed, my life is NEW AGAIN. But I read the hair loss side effects. Will I start to have thinning hair, I am a women, 110 lbs, small frame, is 25mg a day too much to take if I am worried about hair loss?
   A. Hair thinning or hair loss is possible with DHEA in men and women. It is dose dependent and also dependent on how often it is taken. There are many other supplements used for depression and it may be a good idea to use other herbs or supplements while taking a break from the use of DHEA.

DHEA and depression
Q. I am a 56 year old mail. Unfortunately, when I was 51, I began suffering from depression. I believe that in my case the depression caused by too much work related stress. Eventually a doctor prescribed Lexapro, but I had an very adverse reaction to this drug, going into a bad state of mind. From there, I went on Paxil, taking it for four years. I can't say that those 4 years on Paxil give me many fond memories. I learned that doctors really don't know much about depression and brain chemistry. A person has to be careful about these psycho medications. Unfortunately, these drugs are prescribed as though doctors are cooking with seasoning, trying "a little of this" and "a little of that". I learned that DHEA hormone has a benefit to some individuals who are depressed. After taking 5 mg, I saw immediate results. I gave up Paxil about a year ago. There is research on this subject that DHEA is beneficial to some individuals who experience moderate depression. In my case, I believe that DHEA hormone helped.

DHEA production by the body
Humans are thought to make between 10 and 15 mg of DHEA hormone a day. These numbers are lower in women by about 10 to 20 %. DHEA 25 mg is the most common dosage for this hormone supplement sold over the counter. We feel this dosage is too high and can cause side effects.

Testing for blood DHEA or saliva DHEA levels?
Unless you have a medical condition which leads to very low levels of DHEA, it is very difficult to determine the appropriate dosage of DHEA supplements based on testing. At this point we do not recommend routine blood or saliva DHEA testing unless it is interpreted by an experienced medical professional or unless there is a strong medical suspicion that symptoms are due to low DHEA levels. The interpretation of DHEA saliva testing is difficult and different labs may have different ways of testing DHEA making interpretation even more complicated (and hormone levels could easily vary throughout the day). There is no reason to test for DHEA levels if the hormone is being used occasionally. If a person plans to use DHEA as hormone replacement in low doses, such as 1 to 3 mg, we do not see the need to test for DHEA levels.

When did DHEA become available over-the-counter?
DHEA supplements became widely available to the public without a prescription in 1995.

What is the role of DHEA in the human body?
DHEA is converted in the body to androgens (such as testosterone) and estrogens, thus influencing practically every organ and tissue in the body, including the brain. However, the physiological role of DHEA has been studied for over two decades and still eludes final clarification. What we know is that DHEA is secreted by the adrenal cortex, and it exerts its action either indirectly in peripheral tissues after its conversion to androgens and estrogens, or directly as a neurosteroid through the interaction with neuronal receptors.

DHEA danger
High dosages of pregnenolone and DHEA, generally more than 10 mg, cause heart palpitations and irregular beats in some users. The highest dose of these hormones sold over the counter should be no more than 5 or 10 mg, even though they are often available at 10, 25, 50, and even at 100 mg. These hormones are much more powerful that people realize. Just because they are available over the counter does not mean they have been proven to be completely safe.
   As of January 2008, even though DHEA has been sold over-the-counter since the mid 1990s, and millions of people have taken it, there have not been any reports in the medical literature indicating that DHEA has caused fatalities. But it is possible that there may have been fatalities from the use of high doses of DHEA and pregnenolone due to cardiac arrhythmias that were not attributed to the hormones.

DHEA supplement and heart rhythm problems
Q. How do DHEA hormone supplements cause cardiac irregularities? Does DHEA hormone effect catecholamines resulting in extrasystoles?
   A. We don't know how DHEA hormone influences heart rhythm, perhaps it acts directly on the sinus node?

Do DHEA levels in the body stay constant throughout life?
Before puberty, the blood DHEA levels both in males and females is very low, however, it rapidly increases at puberty, and starting in late 20s or early 30s, DHEA levels begin to decrease with age. Whether this represents a harmful deficiency or an age-related adaptation is not known.

Additional human research indicates the following potential DHEA benefits:
DHEA may be of benefit in older men and women with osteoporosis.
DHEA may benefit those with hypopituitarism, a condition in which the pituitary gland fails to secrete a variety of pituitary hormones into the circulation.
DHEA may help reverse bone loss and some of the emotional disturbances associated with anorexia nervosa.
DHEA supplementation improves blood vessel function and insulin sensitivity in middle aged men.
DHEA may benefit patients with Crohn's disease and ulcerative colitis.
DHEA may benefit some women with lupus (systemic lupus erythematosus).
DHEA supplementation in patients with advanced HIV infection results in improved mental function

Human studies with DHEA
There have been dozens of DHEA studies published in the medical literature and the rate of these studies has accelerated ever since DHEA supplements became available over-the-counter. For some reason, some of these DHEA studies do not mention the DHEA side effects that we have encountered in our clinical experience. Sometimes if you don't look for a side effect or sign, you don't find it.

DHEA for adrenal deficiency, Addison's disease
A randomised, controlled trial of long-term DHEA replacement in Primary Adrenal Insufficiency.
J Clin Endocrinol Metab. 2007 Nov 13; Departments of Medicine, Centre for Applied Medical Statistics, Department of Public Health and Primary Care, Psychiatry, and Anatomy and Cambridge Centre for Brain Repair, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ; Dept of Endocrinology, Christchurch Hospital, Christchurch, New Zealand.
In Addison's disease, glucocorticoid and mineralocorticoid deficiencies require lifelong replacement, but the associated near-total failure of DHEA synthesis is not typically corrected. In a double-blind trial, we randomised 106 (44 males, 62 females) subjects with Addison's disease to receive either 50mg daily of micronised DHEA or placebo orally for 12 months, to evaluate its longer-term effects on bone mineral density (BMD), body composition and cognitive function, together with well being and fatigue. Results: Circulating DHEAS and androstenedione rose significantly in both sexes, with testosterone increasing to low normal levels only in females. DHEA reversed ongoing loss of BMD at the femoral neck but not at other sites; DHEA enhanced total body and truncal lean mass significantly with no change in fat mass. There was no significant benefit of DHEA treatment on fatigue, cognitive or sexual function. Supraphysiological DHEAS levels were achieved in some older females who experienced mild androgenic side effects. Although further long-term studies of DHEA therapy, with dosage adjustment, are desirable, our results support some beneficial effects of prolonged DHEA treatment in Addison's disease.

DHEA and diabetes
Dehydroepiandrosterone administration counteracts oxidative imbalance and advanced glycation end product formation in type 2 diabetic patients.
Diabetes Care. 2007 Nov;30(11):2922-7. Oncological Endocrinology Unit, San Giovanni Battista Hospital, Turin, Italy.
DHEA has been shown to prevent oxidative stress in several in vivo and in vitro models. This study aimed to evaluate the effects of DHEA administration on oxidative stress, pentosidine concentration, and tumor necrosis factor (TNF)-alpha/TNF-alpha receptor system activity in patients with type 2 diabetes. DHEA was given as a single daily dose of 50 mg for 12 weeks. After DHEA, plasma levels of reactive oxygen species and hydroxynonenal dropped by 53 and 47%, respectively, whereas the nonenzymatic antioxidants glutathione and vitamin E increased. DHEA treatment also induced a marked decrease of pentosidine plasma concentration in diabetic patients. Moreover, the TNF-alpha/TNF-alpha receptor system was shown to be less activated after DHEA treatment. DHEA treatment ameliorates the oxidative imbalance induced by hyperglycemia, downregulates the TNF-alpha/TNF-alpha receptor system, and prevents advanced glycation end product formation, suggesting a beneficial effect on the onset and/or progression of chronic complications in type 2 diabetic patients.
   Comments by us: Even though this DHEA study showed benefits for patients with diabetes, we would urge caution regarding the high DHEA dosage used in this study. For long term use, we suggest not taking more than 1 to 5 mg of DHEA a day.

Q. What is the right DHEA dosage for diabetes treatment?
   A. We don't think DHEA should be used for diabetes treatment unless all other natural herbs and supplements, along with diet and exercise and weight loss, have first been tried. If DHEA hormone supplements are used for diabetes treatment, we suggest not using more than 2 to 5 mg a a day.

DHEA hormone for low libido
Q. I am 44 yrs old and but lately i am so stressed, my libido is decreasing so bad and lately i started taking Viagra pills, you have erection but you still have low libido. I fell like i am doing something that is not giving me pleasure. It was not like that in the past! i bought a DHEA 50 mg but i did not have courage to take it after reading DHEA side effects. i am planning to start with DHEA 5 mg do you think it will increase libido? Would you think DHEA 5 mg it is a good dose to start?
   A. DHEA hormone may increase libido in some users. However, there are herbs that are safer for the long term to increase libido. A low dosage DHEA supplement can be tried for a few days and then stopped for couple of months. In the meantime, sexual herbs to increase libido can be taken in low dosages.

Do DHEA supplements suppress the adrenal gland's natural DHEA production?
The production of many hormones is controlled by a "feedback loop," which means that when hormone levels get too high, the body is told to make less, and when hormone levels are too low, the body is told to make more. Cortisol, testosterone, and estrogen are all regulated by this feedback. In other words, if a person takes cortisol, or a similar derivative such as prednisone, it will shut off the body's natural production. DHEA appears to be one of the exceptions. There doesn't seem to be an obvious feedback mechanism for DHEA. In other words, DHEA supplements are not likely to stop the body's own production.

Q. Is there a DHEA study that says this natural hormone improves libido?
   A. Yes, there is more than one DHEA study that indicates libido improvement with DHEA supplement use.

DHEA study summary
DHEA is made from cholesterol and is a natural hormone that has been available over-the- counter since the mid 1990s. The availability of DHEA and its popularity have stimulated research by the scientific community regarding the potential uses of this once neglected natural hormone. Although DHEA has side effects in high doses, it does not have the acute toxicity that other non-prescription medicines such as aspirin or acetaminophen (Tylenol) have. Aspirin and acetaminophen are known to cause thousands of deaths and overdoses each year.
   There is little justification for DHEA supplementation in healthy elderly subjects, except perhaps in tiny doses of 1 or 2 mg. However, more research with DHEA may provide the answers we currently lack.

DHEA review and over the counter availability
In our opinion, based on DHEA benefits, side effects, and safety profile, we believe it’s important that the public should continue to have access to DHEA as a dietary supplement. However it is recommended that consumers discuss with their health care provider before undertaking any regular use of this hormone. It is also recommended that the natural health industry itself put forward that dietary supplement companies voluntarily sell and recommend only low dosages of this hormone, such as 5 mg.
   Since 5 mg pills of DHEA are difficult to find, those who plan to take this hormone under medical supervision could open a capsule of 25 mg and take only a small portion, or take a portion of a tablet. You can also find DHEA 10 mg and take a portion of the 10 mg tablet or capsule.

Is DHEA the only adrenal hormone?
More than 150 hormones are known to be synthesized by the adrenal glands. However, the most abundant hormone made by the adrenal glands is DHEA. After DHEA is made by these glands it goes into the bloodstream, and from then on it travels all over the body and goes into our cells, where it is converted into male hormones, known as androgens, or female hormones, known as estrogens. Whether DHEA gets converted predominantly into androgens or estrogens depends on a person's medical condition, age, genetics, and sex. Every person has a unique biochemistry. In males the testicles also make androgens, while in females, before menopause, the ovaries also make estrogens. So the body has developed at least two organs where sex steroids are made. After menopause, the ovaries no longer make estrogens.

Where does DHEA come from? Is there a natural source for DHEA?
In the human body, DHEA is made from cholesterol. DHEA supplements are made commercially from a plant of the Dioscorea family [wild yams] found in abundance in Mexico. Extracts of this plant contain a steroidal saponin called diosgenin which is converted in a laboratory by a series of 6 to 8 chemical reactions into DHEA. A comparable series of reactions is not known to exist in nature and certainly not in humans. Consequently it is highly unlikely, perhaps impossible is a better word, that the ingestion of extracts of the Dioscorea plant will lead to the formation, by metabolic transformation of the relevant plant constituent, to either pregnenolone or DHEA. The human body does not have the enzymes to convert diosgenin to DHEA.

DHEA sulfate test
A DHEA sulfate blood test measures the amount of DHEA sulfate in the blood. This test is used to evaluate the function of the adrenal glands. DHEA-sulfate is tested in women showing symptoms of virilism (male body characteristics) or hirsutism (excessive hair growth). DHEA sulfate levels are also tested in men and women who have signs and symptoms of androgen deficiency.

DHEA level test
Keep in mind that the range of normal blood DHEA levels vary among different laboratories.

Normal DHEA level for women are:
Age 18-30: 70-400 ug/dL
Age 31-40: 40-300 ug/dL
Age 41-50: 30-250 ug/dL
Age 51-60: 20-200 ug/dL
Age 61 plus: 13-120 ug/dL

Normal DHEA level for men are:
Age 18-30: 100-650 ug/dL
Age 31-50: 100-550 ug/dL
Age 51-50: 70-300 ug/dL
Age 51-60: 20-200 ug/dL
Age 61 plus: 30-270 ug/dL

DHEA cream
DHEA cream is sold over the counter in varying dosages. It is difficult to determine the amount of DHEA that would be absorbed through the application of DHEA cream. Plus, various companies will have different potencies of the hormone.

DHEA and woman
DHEA can be used by a woman as well as a man. Women may need a lower dosage since their body weight is less than men.

DHEA and testosterone
DHEA does convert into androstenedione and then to testosterone. As such, DHEA can improve sex drive or libido. However, there are better sexual enhancement options, including an herbal product called Passion Rx.

DHEA and body building
There is no evidence that DHEA use improves body building or muscle growth. The best supplements for body building are creatine and protein powders.

DHEA withdrawal
Q.If I stop taking DHEA will I suffer withdrawal symptoms? Or, does taking it suppress its release by the adrenals, through negative feedback.
   A. We are not aware of withdrawal symptoms having occurred with stopping the use of DHEA hormone.

Additional links of interest
Erectile dysfunction herb information. Although DHEA may help some individuals with erectile dysfunction, there are many herbs that can help this condition with fewer side effects.
Impotence male information regarding natural herbs that are helpful in improving sexual stamina and performance. Although DHEA hormone can help some men with impotence problems, natural and safer herbs are available that are just as or more effective.
Libido herbs and supplements that increase sex drive and sexual pleasure are available in various dosages and extract potencies.
Ray Sahelian, M.D. web site for more information on DHEA hormone benefit and side effects.

DHEA hormone questions
Q. I have a question regarding when to take DHEA supplement pill? In the morning or evening?
   A. We suggest to take a DHEA supplement in the morning.

Q. Would a person with a normal DHEA level benefit from taking a DHEA supplement pill?
   A. We doubt it. DHEA side effects could occur if your body is exposed to a high DHEA dose.

Q. I am a 46 year old woman. My periods stopped when I was almost 44. A doctor was recommended to me .My relationship with her was over the phone and via the internet. She had me do blood work that consisted of free t4. free t3. free testosterone, estrodiol. Igf-1 and Dheas. I was within range but low in some testings. This Doctor was not concerned with the standard ranges as she was coming form an anti aging point of view. I was put on Cytomel 50 mcgs a day and DHEA 50 mgs a day for a year. The last two and a half months I switched my DHEA supplements to a compounding formula. The DHEA dosage was still 50 mgs a day. I never noticed my hair coming out. I woke one morning realizing that my hair had had thinned considerably. The whole experience has been extremely upsetting. Needless to say I am off all of the medication prescribed. My Doctor here believes it be an overdose. I have talked to a few other professionals that believe this to be true as well. I had an appointment with a hair specialist. I spent more time with an assistant/intern. The hair specialist did not factor in the DHEA or Cytomel . My TSH levels came back hyperthyroid. He just told me I had androgentic alopecia and gave me a prescription for Rogaine. I have no desire to take it. I of course want my hair to grow back but the side effects of Rogaine are scary to me. I have been off the meds for almost three months. I have some new hair growth. My hair is still much thinner however. I just started taking some natural transdermal progesterone. I did experience weight loss as well while on Cytomel and DHEA. Would 50 mgs of DHEA for a year cause androgenetic alopecia? It just seems suspect that after taking these meds for a year I have now been diagnosed with androgenetic alopecia.
   A. DHEA use can lead to accelerated hair loss due to excess androgens. After stopping the DHEA some, most, or perhaps almost all the hair may return but the return of the hair varies among individuals. Please keep us updated on the hair growth return. We don't have a full understanding yet regarding the influence of progesterone on hair growth or loss. You may wish to inform your doctors regarding this DHEA page so that they are aware of DHEA hair loss side effects.

Q. I am a 73 year old female, and I take a SR compounded DHEA 5 mg a day. This is based on my bloodwork which showed a low DHEA, less than 15 mcg/dl. I have been on this dose daily for almost 1 year. My last blood level showed that my level is now 22 mcg/dl. I feel much better. Is there any harm in my continuing to take this dose daily? My doctor wants me to take more, but I am comfortable with this amount because I am not having side effects - ie palpitations or hair loss, or libido problems.
   A. The only general statement we can make is to take the least amount of DHEA that works for you.

Additional links
AHCC web site for immune system
Club Natural vitamin site that sells thousands of vitamins, hormones, herbs and natural supplements
Lutein eye information on how to improve eyesight with natural herbs and nutritional supplements
Multivitamin information, best multivitamin sources and effective daily multiples
Tryptophan serotonin information regarding increasing serotonin levels with natural supplements.

Dimpro is a dietary supplement for hormone management
Doctor's Best Total Daily Formula supplement
Dura Flora by Source Naturals
Loquat Respiratory Syrup by Planetary Formulas

Q. I recently had my progesterone and DHEA hormone levels tested. Both hormone levels were low. We did not test my pregnenolone or testosterone hormone levels. I am currently taking progesterone and 7-Keto DHEA hormone. If progesterone and DHEA levels are both low, could this possibly mean that pregnenolone may be low also since it converts to progesterone and DHEA? Could simply supplementing with pregnenolone balance levels of both progesterone and DHEA hormone levels?
   A. The whole issue of hormone supplementation is very complicated and there are no simple answers. It is possible that taking pregnenolone hormone could elevate levels of progesterone and DHEA. However one must focus on treating the whole body rather than treating hormone levels. If a person feels well and has no major symptoms, there is no point in taking hormone supplements even if certain blood hormone levels happen to be slightly low. There is a danger supplementing with hormones and it could turn out to be counterproductive in the long run.

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